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Meant for easy and scientific researchers, immunologists, virologists and molecular biologists, this ebook is a part of a chain which provides severe overviews on chosen features of either melanoma study and the fundamental underlying sciences.

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Expression of the immunoglobulin genes was not examined in these experiments. I n another study, in hybrids between BL cells and PC cells, both the rearranged immunoglobulin p chain and the truncated translocated c-my gene were expressed at high levels. , 1984). The sum of these experiments indicates that both a juxtaposition to an active immunoglobulin locus plus presence of a B cell background capable of activating the immunoglobulin (and c-my by association) genes are necessary to effect the deregulation of c-my seen in BL.

Reference: Taub el al. (1984b). , 1984). , 1986, 1987). There is a correlation between the type of actively expressed immunoglobulin allele and the site of the chromosomal breakpoints. For 30 CHARLOTTE A. SPENCER A N D MARK CROUDINE example, most BL cells are IgM producers and most breakpoints occur in the p switch region. , 1985). , 1984). The immunoglobulin heavy-chain enhancer ( E p )is only occassionally associated with the translocated c-myc allele. As E p is located between]" and S,, it is translocated to the upstream region of the c-myc allele that remains on chromosome 8 in most of the common BL t(8;14) translocations, and therefore does not act in cis to enhance expression of the translocated c-myc gene.

Cell. B i d . 6, 3481-3489. Bentley, D. , Brown, W. , and Groudine, M. (1989). Genes Dev. 3, 1179- I 189. , and Adams, J. M. (1983). EMBOJ. 2, 2375-2383. , Jansen, H. , and Patschinsky, T. (1987). Oncogene 1,97-109. , and Jeanteur, P. (1985). Nature (London)317,433-435. , DeClerk, Y. , and Mock, A. (1987). Cancer Res. 47, 3808-3814. Boles, T. , and Hogan, M. E. (1987). Biochemistry 198,367-376. , and Ross, J. (1988). Mol. Cell. Biol. 8, 1697-1708. , and Ross, J. (1989). Mol. Cell. Biol. 9, 1996-2006.

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