By George Klein, Sidney Weinhouse, Alexander Haddow (Eds.)
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From its advent, oncological chemotherapy has been weighted down through its negative selectivity simply because so much antiproliferative medicines are poisonous not just to tumor cells but additionally to special populations of the body’s non-neoplastic cells. the consequent issues of unintended effects are compounded by means of problems in predicting the specified efficiency of chemotherapy in person sufferers.
It's been well-known for a few years that cancers originating within the breast and prostate gland are often 'endocrine-dependent. ' conventional thera pies incorporated surgical endocrine ablative tactics or pharmacologic hor mone management, either designed to antagonize the stimulatory results of intercourse steroid hormones.
Gastric melanoma continues to be the most typical explanation for melanoma demise on this planet, even supposing in so much nations, with the remarkable exception of the U.S., its prevalence is slowly declining. In statistical phrases, gastric melanoma is hence the main ambitious of melanoma kinds, and its regulate is a urgent factor.
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Extra resources for Advances in Cancer Research, Vol. 13
1969). IV. lrnrnunotherapy The model systems used in experimental cancer research do not accurately reflect the important clinical situation. I n animals, immunotherapeutic procedures are usually assessed by their effect on the growth of the primary tumor. I n man, localized disease can in most cases be effectively eradicated by surgery or by radiotherapy and the problem is to deal with metastastic spread. We have argued that circulating cytotoxic antibody is necessary to prevent blood-borne tumor cells from establishing themselves as new metastases but that existing metastastic lesions can only be effectively attacked by immune lymphoid cells.
The mode of action, as well as the nature of the active principle in the subcellular fractions has not been determined. Our working hypothesis was t ha t RNA from the immunoblasts produced a phenotypic transformation in some of the host cells and caused these to acquire immunologically specific antitumor activity (cf. Mannick and Egdahl, 1964; Wilson and Wecker, 1966). In the initial experiments we wished to use a preparation that contained all of the RNA present in the lymphocytes. The method of extraction needed to achieve this gave an extract that contained in addition t o the RNA considerable amounts of DNA and some trazes of protein.
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